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The effect of alendronate and ultraviolet treatment on bone-implant interface
EAO Online Library. Lee J. Oct 9, 2018; 232621; P-BR-70
Jun Lee
Jun Lee
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Recently, the use of ultraviolet (UV) treatment in increasing bone-to-implant contact has attracted much attention and application of bisphosphonates (BPs) has been reported to improve bone healing. Alendronate (ALN) is one of the most potent nitrogen-containing BPs and is commonly used for the treatment of metabolic bone disorders. The effects of ALN are attributed to the suppression of bone resorption mediated by osteoclasts and to the exertion of anabolic effects on osteoblasts.**Rapid and stable fixation of dental implants is crucial for successful treatment. Herein, we examined whether the simultaneous treatment of titanium implants with ultraviolet (UV) and alendronate (ALN) synergistically improved the bone-to-implant contact.We assessed the in vitro effects of UV radiation-treated (UV+ ALN-), ALN soaked (UV- ALN+), and UV radiation ALN-treated (UV+ ALN+) titanium implants on cell proliferation, cytotoxicity, cell adhesion, and osteoblast differentiation using MG-63 osteoblast-like cells by the assays of MTS, live dead, scanning electron microscopy (SEM), alkaline phosphatase (ALP) activity, and alizarin red S (AR-S) staining, respectively.MG-63 cells cultured on UV+ ALN+ implants showed significantly higher cell proliferation, ALP activity, and calcium mineralization than those cultured on other implants (P < 0.05). Furthermore, SEM observation showed the highest increase in cell attachment and growth on the UV+ ALN+ implants.Treatment of titanium surfaces with UV and ALN may synergistically enhance osteoblastic differentiation and mineralization in vitro.
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