Online Library
Particle Simulation of Alveolar Bone Regeneration and Angiogenesis using platelet-rich plasma (PRP)
EAO Online Library. Matsuo M. Oct 9, 2018; 232617
Masato Matsuo
Masato Matsuo
Login now to access Regular content available to all registered users.
Discussion Forum (0)
Rate & Comment (0)
Dental implants are a major treatment option in modern dentistry. However, it is difficult to insert successfully into the narrow width and the low height of the jawbone. Application of platelet-rich plasma (PRP) is extensively used in dental bone regeneration therapy, as it contains many growth factors. These factors are thought to accelerate the regrowth of blood vessels and bone.To examine the relationship between the bone formation and vascular changes, a vascular resin cast model was examined. And angiogenesis model and reaction-diffusion model are constructed and calculated at the same time by computed Particle Simulation as the coupled analysis model of bone formation. All the animal experiments were conducted in compliance with the protocol which was reviewed and approved by the Institutional Animal Ethics Committee (Permit Number 16045).The mandibular premolars of beagle dogs were extracted. PRP was made and applied to one side of the dentition, with the other side remaining untreated as a control. Microvascular resin injection was performed from maxillary artery after14, 30, and 90 days. The soft tissue was digested with proteinase solution. These specimens were examined by scanning electron microscope (SEM). The computational domain was set to a cube of 1mm3 to eliminate the influence of boundaries from captured SEM images. Ninety particles were arranged in various directions+ therefore, a total of 729,000 particles covered the entire area. Time step width was set to 500 steps in a day. After 14days, Blood vessels and newly formed bone were regenerated along the pre-existing alveolar bone. In the center of the socket bone formation was not occured in Control group . In the PRP Group, Blood vessels and newly formed bone were regenerated in the socket, including the center portion of the socket. After 30days in the control] Sockets were filled with porous newly formed bone, which was observed near blood vessels. In the PRP group, Remarkable amounts of porous newly formed bone were seen in the sockets. Bone trabeculae and bone marrow vessels began to form. After 90 days in control group, Normal - like bone structure was achieved. Bone trabeculae and bone marrow vessels was observed in this period. Regenerated thick bone trabeculae and networks of blood vessels in the bone marrow appeared in PRP group. From the results of numerical analysis and experiment, PRP is supposed to promote angiogenesis and bone regeneration.Major factors of bone regeneration were modeled and analyzed in this study. In the angiogenesis model, blood vessels grew from the starting points and covered the entire area of the vessels. In the bone formation analysis model, which is affected by mechanical factors. Taken together with our observations, these results suggest that the most prominent benefits of PRP use are safety and acceleration of vascularization and bone formation.
Code of conduct/disclaimer available in General Terms & Conditions
Anonymous User Privacy Preferences

Strictly Necessary Cookies (Always Active)

MULTILEARNING platforms and tools hereinafter referred as “MLG SOFTWARE” are provided to you as pure educational platforms/services requiring cookies to operate. In the case of the MLG SOFTWARE, cookies are essential for the Platform to function properly for the provision of education. If these cookies are disabled, a large subset of the functionality provided by the Platform will either be unavailable or cease to work as expected. The MLG SOFTWARE do not capture non-essential activities such as menu items and listings you click on or pages viewed.

Performance Cookies

Performance cookies are used to analyse how visitors use a website in order to provide a better user experience.

Google Analytics is used for user behavior tracking/reporting. Google Analytics works in parallel and independently from MLG’s features. Google Analytics relies on cookies and these cookies can be used by Google to track users across different platforms/services.

Save Settings